You might already be aware of the actors' history off camera, which mainly involves Ryan cracking jokes about having previously dated the iconic comedian and trailblazing sitcom star.
Ryan, who's been in a relationship with his now-wife Blake Lively for almost a decade, went on to call Betty "the one and only," which I think everyone can agree is a universally accurate description.
Tough luck, Ryan. The Deadpool actor, who naturally sang Betty's praises alongside Sandra Bullock in their own individual comments to People, also responded to her playful gibe on social media.
We'll keep you posted about any further developments on this front.
Ryan is one of many prominent celebrities set to appear in Betty's birthday documentary, so stay tuned.
